In silico QSAR (Quantitative Structure–Activity Relationship) tools have become essential for predicting toxicity, skin sensitization, and environmental impact early in product development. Life Cycle Sustainability Assessment (LCSA) is, however, increasingly used in the cosmetics sector to support regulatory compliance, packaging design decisions, and substantiation of environmental claims. Life cycle–based methodologies are becoming central to meeting evolving European regulatory and...

Prostaglandin analogues (PGAs) are synthetic, first-line, once-daily eye drops that reduce elevated intraocular pressure (IOP) in glaucoma and ocular hypertension by increasing uveoscleral outflow. These compounds mimic naturally occurring prostaglandins, specifically targeting receptors to relax eye muscles and enhance aqueous humor drainage. There is no formal ban on the use of prostaglandin analogues in cosmetic products in the EU as of March 2026. However, the situation is very close to...

Reproductive Toxicity Category 1B and hazard statement May damage fertility. May damage the unborn child. In November 2023, the Risk Assessment Committee (RAC) of the European Chemicals Agency (ECHA) adopted an opinion to classify Tea Tree Oil (Melaleuca alternifolia) as a Category 1B Reproductive Toxicant (Repr. 1B - H360) under the EU Classification, Labelling, and Packaging (CLP) regulation. This classification indicates a high, harmonized concern that the substance may damage fertility or...